Lower estimated bone strength and impaired bone microarchitecture in children with type 1 diabetes
نویسندگان
چکیده
منابع مشابه
[Bone mineralization in children and adolescents with type 1 diabetes].
OBJECTIVE To evaluate the occurrence of osteopenia and the prognostic factors of bone mass in a pediatric group with type 1 diabetes. METHODS The following parameters were analyzed in a group of 23 patients with type 1 diabetes aged 10.9 -/+ 2.9 years: bone mineral density, serum C peptide, glycosylated hemoglobin, serum calcium, serum alkaline phosphatase, serum phosphorus and calciuria. Cli...
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PURPOSE Increasing evidence supported that semaphorin 3A (Sema3A), insulin-like growth factor (IGF)-1 and β-catenin were involved in the development of osteoporosis and diabetes. This study is aimed to evaluate whether Sema3A/IGF-1/β-catenin is directly involved in the alterations of bone microarchitecture and bone strength of diabetic rats. METHODS Diabetic rats were induced by streptozotoci...
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The pathophysiological mechanism of increased fractures in young adults with type 1 diabetes mellitus (T1DM) is unclear. We conducted a case-control study of trabecular bone microarchitecture and vertebral marrow adiposity in young women with T1DM. Thirty women with T1DM with a median age (range) age of 22.0 years (16.9, 36.1) attending one outpatient clinic with a median age at diagnosis of 9....
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BACKGROUND/AIMS In a randomized controlled clinical trial in kidney transplant recipients (NCT01377467) we have recently shown that RANKL inhibition with denosumab significantly improved areal bone mineral density (aBMD) when given during the first year after transplantation. The effect of denosumab on skeletal microstructure and bone strength in kidney transplant recipients is not known. MET...
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ژورنال
عنوان ژورنال: BMJ Open Diabetes Research & Care
سال: 2020
ISSN: 2052-4897
DOI: 10.1136/bmjdrc-2020-001384